4/30/2023 0 Comments Grape seed extract benefitsAnother use of grape seed extract is reducing blood pressure in people with hypertension. Grape seed extract also has been beneficial in treating edema, an excessive accumulation of fluid in tissue. In one European study, researchers found that treatment with grape seed extract quickly relieved a chronic condition of poor circulation in the veins. Components bind to the walls of the capillaries, making them less likely to break down with the effects of aging. Cardiovascular diseaseĮuropean studies have shown procyanidins to be useful in treating blood vessel disorders, such as fragile capillaries and poor circulation in the veins. A 2003 study found that grape seed extract worked well in replacing estrogen and blunting hypertension in postmenopausal women. More recent research suggests that grape seed extract may work at the genetic level, activating a gene that stops oxidation of bad cholesterol. Further research led to the OPCs concentrated in grape seeds. This was credited to their widespread consumption of red wine. Its antioxidant properties were realized in the 1980s with the socalled French paradox, in which researchers discovered that the French had low rates of heart disease even though their diet was high in cholesterol. Grape seed extract is a relatively new supplement in the United States, although it has been used in Europe for several decades. Tyler, dean emeritus of the Purdue University School of Pharmacy and Pharmacal Sciences, the procyanidin compounds found in grape seed extract are useful in treating vascular disorders They also are antioxidants, or freeradical scavengers, that help prevent some age-related cancers and atherosclerosis. It is available as an over-the-counter supplement. Most of the research on grape seed extract has been done in Europe, so many of its reported benefits have not been reviewed or approved by the U.S. They also are able to cross the stubborn blood-brain barrier, providing antioxidant protection to the brain and nervous system. OPCs in the extract are water-soluble, making them easily absorbed by the body. Procyanidins, a group of compounds found in the extract, are thought to increase the effectiveness of other antioxidants, especially vitamin C and vitamin E, by helping them regenerate after neutralizing free radicals in the blood and tissue. Its antioxidant properties are believed to help slow the aging process. It has a wide range of therapeutic uses, from preventing cancer and cardiovascular disease to alleviating symptoms of allergies, ulcers, and cataracts. Grape seed extract is a mixture of complex compounds. However, the grape seed extract is more widely recommended for its lower cost and because it contains an antioxidant not found in pine bark. The primary sources of OPCs are pine bark extract and grape seed extract. Laboratory studies have indicated OPCs are much more effective than vitamin C and vitamin E in neutralizing free oxygen radicals, which contribute to organ degeneration and aging in humans. Grape seed extract is the primary commercial source of a group of powerful antioxidants known as oligomeric proanthocyanidins (OPCs), also generically called pycnogenol, a class of flavonoids.
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